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Scientists resurrected 1918 flu antibodies from elderly survivors

antibodies | biotechnology | immune system | infectious disease | viruses

Ninety years after the sweeping destruction of the 1918 flu pandemic, researchers at Monroe Carell Jr. Children’s Hospital at Vanderbilt have recovered antibodies to the virus – from elderly survivors of the original outbreak.

Anti-Apolipoprotein-H antibodies

antibodies | autoantibodies | autoimmune diseases


schematic representation of antibody. In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called (Anti β2 glycoprotein I antibodies) comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and strongly associate with thrombitic forms of lupus. and it was proposed that AAHA is responsible for lupus anticoagulant. Antiphospholipid antibodies bind phospholipids at sites similar to anti-coagulation binding sites and augment anti-coagulation activity as one category of anti-cardiolipin antibodies (ACLA-A) whereas a second category of antibody (ACLA-B) does not indicating that AAHA are a A subset of ACLA. AHAA only inhibits the coagulation activity in the presence of Apo-H and the AAHA componet of ACLA correlates with a history of freqeunt thrombosis. . This can be contrasted with Lupus anticoagulant which inhibits agglutination in the presence of thrombin. A subset of AHAA appear to mimic the activity of lupus anticoagulant and increase Apo-H binding to phospholipids.

structure of Apolipoprotein H

Scientists find bird flu antibody

antibodies | immune system | immunology | infection | infectious disease | viruses

Scientists working in Switzerland, Vietnam and the United States say they have isolated antibodies that they hope could offer protection against several different strains of the virus simultaneously.

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