Researchers have new insight into the mechanisms that underlie a pathological increase in the size of the heart. The research, published by Cell Press in the October 24th issue of the journal Molecular Cell, may lead to the development of new strategies for managing this extremely common cardiac ailment that often leads to heart failure.

Amenacier writes "Melbourne scientists recently discovered that stem cells isolated from human fat could be made to turn into beating heart muscle cells when cultured with rat heart cells. This discovery may lead to the use of fat stem cells in repairing cardiac damage, or fixing such cardiac problems as holes in the heart. It is proposed that culturing the stem cells with rat heart cells allows them to differentiate into heart muscle through signals from the rat cells. In the future it may be possible to inject/transplant the stem cells into the damaged area and have them naturally differentiate into the type of cell required, with only the natural stimuli provided by surrounding cells, without any danger of rejection by the body. Quoting: 'The next step is to implant the human heart cells onto the damaged heart of a laboratory rat to see whether they repair the heart. Then they would be trialled in higher species such as sheep and pigs before human applications could be considered. Clinical application could be five years away ...'" The Age has a multimedia treatment (Flash) of the discovery.

An anonymous reader writes "Serious heart surgery usually involves stopping the organ and keeping the patient alive with a cardiopulmonary bypass machine. But this risks brain damage and requires a long recuperation. Scientists at Harvard University and Children's Hospital Boston have now developed a device that lets surgeons operate on a beating heart with a steady hand. The 'robotic' device uses 3-D ultrasound images to predict and compensate for the motion of the heart so that the surgeon can work on a faulty valve as it moves. The approach should improve recovery times and give a surgeon instant feedback on the success of the procedure, the researchers say. Here's a (slightly gory) video of the device in action."

Hugh Pickens writes "Researchers have found that the winner's curse may apply to the publication of scientific papers and that incorrect findings are more likely to end up in print than correct findings. Dr John Ioannidis bases his argument about incorrect research partly on a study of 49 papers on the effectiveness of medical interventions published in leading journals that had been cited by more than 1,000 other scientists, and his finding that, within only a few years, almost a third of the papers had been refuted by other studies. Ioannidis argues that scientific research is so difficult — the sample sizes must be big and the analysis rigorous — that most research may end up being wrong, and the 'hotter' the field, the greater the competition is, and the more likely that published research in top journals could be wrong. Another study earlier this year found that among the studies submitted to the FDA about the effectiveness of antidepressants, almost all of those with positive results were published, whereas very few of those with negative results saw print, although negative results are potentially just as informative as positive (if less exciting)."

Ponca City, We love you writes "Legendary Blue Grass musician Eddie Adcock has undergone brain surgery to treat a hand tremor, playing his banjo throughout to test the success of the procedure. Adcock suffers from essential tremor, a condition where there is a continuing deterioration in areas of the brain that control movement causing a tremor that usually appears when the person tries to act or move. Deep brain stimulation can be used to treat the movement difficulties of both Parkinson's and essential tremor by sinking an electrode into the thalamus, a deep brain area that is part of the motor loop — a circuit that helps coordinate movement. Surgeons placed electrodes in Adcock's brain and fitted a pacemaker in his chest, which delivers a small current that shuts down the region of his brain causing the tremors. The most sensible thing to do was to tweak the system while Adcock was playing the banjo to optimize the effect for the thing that's most important to him."

Roland Piquepaille writes "German researchers at the Christian-Albrechts-Universität zu Kiel (CAU) think they've proved that genetic information can be controlled by light. The group studied the interaction between the four DNA bases — adenine (A), cytosine (C), guanine (G), and thymine (T) — by using femtosecond time-resolved fluorescence spectroscopy. The researchers think that they've demonstrated that DNA strands differ in their light sensitivity depending on their base sequences. The team thinks that it might be possible in the future to repair gene mutations using laser radiation. One of the project leaders said that 'it might even be possible under some circumstances to make transistors from DNA that would work through the hydrogen bonds.' It's not the first time I've heard about DNA computing, but this new approach looks promising."

fprintf writes "A recent NY Times article discusses links between personal music players and hearing loss. This is not anything new; personally, I have hearing loss from listening to my Sony Walkman cassette player many years ago. However, given the widespread use of the personal music players, I see people using earbuds everywhere; is there a technical solution to the potential danger?"

Researchers from the Genome Institute of Singapore (GIS) and its collaborators have now identified for the first time a new gene that may confer susceptibility to pulmonary tuberculosis. Their finding

You know it’s good for you in other ways, but could eating your broccoli also help patients with chronic lung disease? It just might. According to recent research from Johns Hopkins Medical School,

A new study has shown that an investigational drug (R207910, currently in clinical trials against multi-drug resistant tuberculosis strains) is quite effective at killing latent bacteria. This revelation suggests that R207910 may lead to improved and shortened treatments for this globally prevalent disease.