Tricyanoaminopropene (TRIAP, TCAP, Malononitrile Dimer, 1,1,3-tricyano-2-amino-1-propene) is a nootropic drug which mimics the function of nerve growth factor and increases the growth of nerves and tissue regeneration both in isolated tissuesPaul JW, Quach TT, Duchemin AM, Schrier BK, DaVanzo JP. 1,1,3 tricyano-2-amino-1-propene (Triap): a small molecule which mimics or potentiates nerve growth factor. Brain Research. Developmental Brain Research. 1990 Aug 1;55(1):21-7. PMID 2208638 and in vivo. It stimulates the action of the enzyme choline acetyltransferase, resulting in increased acetylcholine production.Paul JW, DaVanzo JP. 1,1,3 Tricyano-2-amino-1-propene (Triap) stimulates choline acetyltransferase activity in vitro and in vivo. Brain Research. Developmental Brain Research. 1992 Jun 19;67(2):113-20. PMID 1511511 This then results in increased synthsis of RNA in many different tissues in the body. Dhindsa KS, Enesco HE. Radioautographic study of the effect of malononitrile dimer on RNA synthesis in mice. Acta Anatomica (Basel). 1978;100(1):44-50. PMID 899675 However it also suppresses the production of thyroxine, causing temporary hypothyroidism which returns to normal once the drug is discontinued.Dhindsa KS. Histological changes in the thyroid gland of the mouse following treatment with 1, 1, 3-tricyano-2-amino-1-propene. Acta Anatomica (Basel). 1980;106(4):468-72. PMID 7386168